Clinical studies prove B12 for vitiligo supplementation works better when combined with folic acid. Synthesis of melanin within a melanocyte is controlled by the activity of an enzyme, tyrosinase, which is localized in an intracellular organelle – the premelanosome. Upon activation of tyrosinase, melanin is deposited with the organelle. After complete melanization, the premelanosome is known as a melanosome. Melanosomes are delivered to surrounding keratinocytes of the skin cells within the shaft of the graying hair by the process known as cytocrine secretion. Folic acid contains three components:
- para-aminobenzoic acid
- L-glutamic acid.