B12 and Folic Acid for Vitiligo

Clinical studies prove B12 for vitiligo supplementation works better when combined with folic acid. Synthesis of melanin within a melanocyte is controlled by the activity of an enzyme, tyrosinase, which is localized in an intracellular organelle – the premelanosome.  Upon activation of tyrosinase, melanin is deposited with the organelle.  After complete melanization, the premelanosome is known as a melanosome.  Melanosomes are delivered to surrounding keratinocytes of the skin cells within the shaft of the graying hair by the process known as cytocrine secretion. Folic acid contains three components:

• pteridine
• para-aminobenzoic acid
• L-glutamic acid.

Free pteridine is the coenzyme for the enzymatic hydroxylation of phenylalanine to tyrosine.  Thus a deficiency in pteridine causes a deficiency in tyrosine. Para-aminobenzoic acid (PABA) (a component of folic acid) is needed for melanogenesis.  PABA helps in the utilization of pantothenic acid.  Thus folic acid in its whole is more effective than administering some of its parts in stimulating/ supporting/ feeding pigment production. Defective synthesis of myelin results from B12 deficiency. Folic acid and vitamin b12 require each other’s presence in biological reactions.  Reactions are accelerated by supplying the two vitamins together.  Furthermore, taking folic acid without taking b12 will deplete the body’s b12 supply and can also mask b12 deficiency.  A deficiency in B12 can lead to a deficiency in folic acid and vice versa. Vitamin C enhances the rate of transformation of tyrosine to dopa.  Vitamin C is also needed for the metabolism of folic acid. Melanin provides protection against ultraviolet light damage from sunlight and other light sources. The movement of melanosomes within melanocytes in skin can be accelerated by exposure to sunlight or ultraviolet light. This formula is good for conditions of deficient or absence of functional melanocytes.  Coupled with the stimulation provided by sunlight or ultraviolet light can be done. We’ve incorporated the two, plus copper and zinc, into a formula specifically for those with vitiligo. Get the nutritional therapy needed to support the reappearance of color with Recouleur® Vitamins.